dnaseI.map.news.itemDNaseI chromatin accessibility maps from ENCODE are now integrated into the Biophysical Browser. Any of the ENCODE DNaseI data for a particular tissue type can be loaded in the Browser as an affinity-based positional prior that models DNA accessibility. Importantly, these affinity-based positional priors can be included in all the protein-DNA occupancy calculations – which greatly reduces false positive binding predictions in regions of inaccessible DNA.


Dr. Todd Riley
Assistant Professor of Biology
University of Massachusetts Boston
100 Morrissey Blvd. | ISC Building Room 4730
Boston, Massachusetts 02125
Phone: (617) 287-3236