Recent examination of massive sequencing (metagenomics) approaches to analyze the composition of bacterial communities of complex milieu including sea water,38 provide an abundant source of molecular sequence data for analysis. It is generally recognized, particularly in systems responsible for the synthesis of diverse antibiotics, that, for example, nonribosomal peptide synthesis occurs within a molecular complex composed of modules or subunits grouping peptide synthetase modules and associated enzymatic activities. However, research, teaching, and provision of infrastructure and core resources are coordinated nationwide, thus greatly increasing each group's efficiency. Thus, topics for research papers on bioinformatics range from some general facts to such specific issues as: Unfortunately, we cannot tell you about all peculiarities of writing good research papers on bioinformatics. We know of no case in which a protein target has been identified with substantial bioinformatics support and, for this protein, a drug developed and put on the market, successfully. Try to make it as specific and clear as possible. Despite the enormous flexibility of genomes, the corresponding metabolic synthesis networks follow specific inherent rules that are responsible for their rigidity.39 Evolutionary designed strategies are ideally suited to utilize this genomic flexibility to adapt desired phenotypes to balance the metabolic network states required for optimal performance. We use cookies to help provide and enhance our service and tailor content and ads. We anticipate that this development will occur before the advent of ‘computer drugs’ having a substantial share of the pharmaceutical marketplace. 1. This chapter introduces the three scientists whose initiatives 50 years ago led to the birth of the science of bioinformatics, and briefly discusses their contributions. A recent study has found that the interest of researchers in these topics plateaued over after the early 2000s [1]. For example, as the presence of conserved sequence motifs and a modular organization of nonribosomal peptide synthetases often assembled into single bacterial operons, a specific sequence search algorithm can be developed to screen public database resources. The word ‘bioinformatics’ was first used in 1968 and its definition was first given in 1978. Marianna Milano, in Encyclopedia of Bioinformatics and Computational Biology, 2019. However, we can share the main secrets of how to succeed with your project. Back to results. The search engine as discovery and integration infrastructure has been essential to the ongoing success of this approach. Although at the time it was not called bioinformatics, the application of computers in protein-sequence analysis and tracing protein evolution was the rudimentary form of contemporary bioinformatics. Therefore, a coherent picture of how all of these components will act in concert, for example to systematically search for protein targets, cannot be given yet. Text Mining. Anyway, we suppose there is not much you can do about the situation, and your research paper on bioinformatics should be finished anyway. Signal processing. The main components of bioinformatics are (1) the development of software tools and algorithms and (2) the analysis and interpretation of biological data by using a variety of software tools and particular algorithms. Over the past seven years, department faculty have published over 300 bioinformatics research papers, received around $3M in external funding for bioinformatics research, directed and graduated 25 Ph.D. students in bioinformatics, and have been recognized for … As implied above, the Internet and Web are widely used within the biomedical research community to exchange data, applications, and literature. Installation and use of caGrid SOA “middleware” infrastructure (specialized software that connect data and applications) requires bioinformatics technical expertise. Although hardware is increasingly not a rate-limiting step in using IT, the complexity of installation still requires computer professionals. When will the field be mature enough to provide the first successes in pharmaceutical and clinical practice? The identification of genes involved in the metabolic synthesis of natural products by genome sequence analysis can be complemented by the analyses and modeling of natural products production. Additionally, it also holds some other fields rather than this. Top 10 Hottest Research Topics in Computer Science. This next generation use of the Web uses Web-based-services where data is electronically transmitted in structured fashion interpretable by computers and applications share their capabilities by receiving this electronic information without having to be installed locally. Zhang, S.-L. Liu, in Brenner's Encyclopedia of Genetics (Second Edition), 2013. Copyright © 2020 Elsevier B.V. or its licensors or contributors. The bioinformatics community supports this through the ethos of open source and open access to its data and tools. Bioinformatics can be defined as “the application of computational tools to organize, analyze, understand, visualize and store information associated with biological macromolecules” (Luscombe et al., 2001; From: Encyclopedia of Bioinformatics and Computational Biology, 2019, S.-Y. 1.1 OVERVIEW. If you use any content written by Writing-Services.org, it should be referenced accordingly. It should briefly explain the main problem of your work, its importance, and methods used to solve it. Since Ada Lovelace, an English mathematician, wrote the first algorithm of a computer language; computer science witnessed a big boost. These three scientists were Margaret Dayhoff, Richard Eck, and Robert Ledley. Research topics on Bioinformatics . The efficiency of data mining algorithms. Content and services provided by Writing-Services.org are to be used for research purposes only. This chapter discusses the considerable progress in infectious diseases research that has been made in recent years using various “omics” case studies. In its first 15 years of existence, SIB grew from five groups and 30 scientists to a community of 46 groups with more than 600 affiliated bioinformaticians carrying out bioinformatics and computational biology work in fields such as proteomics, transcriptomics, genomics, systems biology, structural bioinformatics, evolutionary bioinformatics, modeling, imaging, biophysics, population genetics, and clinical bioinformatics. These approaches have transformed the finance and business communities (as well as the military) and represent the substance of e-business. Infrastructure, applications, and data resources that adhere to a common set of standards constitute a services- oriented architecture (SOA). Among these, R is becoming one of the most widely used software tools for bioinformatics. This question is hard to answer; also, we have not undertaken a comprehensive survey of successes that can already be reported. These data are useful in comparative genome analyses to identify genes directly involved, for example, in nonribosomal peptide synthesis (peptide synthetase), modifying enzymes, or other genes coding the production of certain natural products. However, more technologically sophisticated alternative approaches to the use of the Internet have been slow to penetrate biomedicine. To address the need for data science skills and knowledge, JAX offers a bioinformatics training program that equips researchers with the critical data science skills needed to move research forward. Make note that this area of study is ever changing and hence new topic ideas are the norm. Hello, I have a question relative to career progression for bioinformatics staff. By continuing you agree to the use of cookies. There must be some aspects of modern tech that will catch a student’s fancy enough to pursue for academic research. In all of these cases, our informal inquiries have yielded substantial support for the fact that bioinformatics procedures have entered clinical practice. Bioinformatics and the management of scientific data are critical to support life science discovery. For this purpose, research papers are assigned to them in this field of computer science. ... Computer Science & IT (447) Condensed Matter Physics (120) Data Analysis (597) Dentistry (39) Development Studies (30) Bioinformatics describes the computational analysis of genomes and macromolecular structures on a large scale. As the name bioinformatics applications in computer science symbolizes that, this field associated with computer science, mathematics, biology, and statistics for determining and depicting the biological data. Swiss bioinformaticians created software for the comparison of DNA sequences, developed programs for the analysis of experimental protein data, invented tools for modeling the three-dimensional structures of proteins, and built databases containing key information about protein sequences. The Computing Research Association (CRA) is a leading computer science advocacy organization whose mission is to unite industry, academia, and government. Make sure all tables are accurate, are not overloaded with data, and present the results of your work clearly. Yi-Ping Phoebe Chen, ... Paolo Carloni, in Comprehensive Natural Products II, 2010. What this means is that your research paper on bioinformatics can also make some useful contribution, at least, if you are good at this discipline. This chapter explains the various possibilities of pan-genome, transcriptional reshaping and also enormous progress of proteomics study. This implies an appropriate shape of the binding pocket to be able to bind to small-molecule drugs, for instance. With the increased numbers of fully sequenced microbial genomes, including those of well-known bacterial producers of natural products, it has become clear that the genomic and metabolic capacity of these microorganisms is much higher than initially anticipated. Copyright @ 2020 Writing-Services.org. Discipline. Besides that, you are spoilt for choice from a wide variety of topic possibilities. However, in our opinion, the general picture is as follows. Like business-to-business applications supporting e-commerce, caB2B uses components drawn from the nationwide caBIG partners (Figure 24-9). Formulate the main point of your research paper on bioinformatics. ScienceDirect ® is a registered trademark of Elsevier B.V. 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URL: https://www.sciencedirect.com/science/article/pii/B9780123749840001558, URL: https://www.sciencedirect.com/science/article/pii/B9780080453828007292, URL: https://www.sciencedirect.com/science/article/pii/B978141603703310024X, URL: https://www.sciencedirect.com/science/article/pii/B008045044X000882, URL: https://www.sciencedirect.com/science/article/pii/B9780124104716000049, URL: https://www.sciencedirect.com/science/article/pii/B9780444536327011242, URL: https://www.sciencedirect.com/science/article/pii/B9780128096338203671, URL: https://www.sciencedirect.com/science/article/pii/B9780123739322000235, URL: https://www.sciencedirect.com/science/article/pii/B9780123848901000182, URL: https://www.sciencedirect.com/science/article/pii/B9780127999425000172, Encyclopedia of Bioinformatics and Computational Biology, 2019, Brenner's Encyclopedia of Genetics (Second Edition), Modern Methods in Natural Products Chemistry, Yi-Ping Phoebe Chen, ... Paolo Carloni, in, The Molecular Basis of Cancer (Third Edition), http://gforge.nci.nih.gov/projects/cagrid-1-0, Computing Languages for Bioinformatics: R, Encyclopedia of Bioinformatics and Computational Biology, Encyclopedia of Applied Ethics (Second Edition), Omics, Bioinformatics, and Infectious Disease Research, Konrad H. Paszkiewicz, Mark van der Giezen, in, Genetics and Evolution of Infectious Disease, Next-Generation Sequencing, Bioinformatics, and Infectious Diseases, Genetics and Evolution of Infectious Diseases (Second Edition), Biochemical and Biophysical Research Communications. As most of biology and medical sciences is becoming more and more “big data,” the introduction of bioinformatics in almost all subdisciplines has led to multiple interpretations of what bioinformatics actually entails. Kenneth H. Buetow, in The Molecular Basis of Cancer (Third Edition), 2008. However, we are encouraged by promising recent developments that incremental progress will be made along this route and that important intermediate results will find their way into pharmaceutical and medical practice not only in the long term but also in the more immediate future. An alternative is to leverage the power of the Internet. We expect bioinformatics procedures such as the computational analysis of gene expression data for the determination of the type and state of a disease or the computational analysis of the resistance of a pathogenic strain to drug therapy to become increasingly widespread in clinical practice over the next few years. Cloud computing, big data, Hadoop; Machine learning; Artificial intelligence; Functional genomics 30 Great Research Paper Topics for Computer Science. The choice of a topic should depend solely on your background knowledge and understanding of various bioinformatics issues. In 1998, Swiss bioinformatics became organized and the five existing bioinformatics groups, representing 30 scientists from five academic institutions, joined forces to create the SIB (Swiss Institute of Bioinformatics), a nonprofit foundation (www.isb-sib.ch). Research Papers on Bioinformatics: Biology and Computer Science? With semantic interoperability, diverse applications can use multiple, distributed sources of data and share the output of their analysis with other applications. About one or two decades ago, people saw biology and computer science as … Of these, Margaret Dayhoff’s contributions stood out the most and she is often credited as being the pioneer in bioinformatics for her varied contributions, including developing the first amino-acid substitution matrix for studying protein evolution. Two examples of applications that use the caBIG network to create a virtual bioinformatics platform are summarized in the following paragraphs. Thus, topics for research papers on bioinformatics range from some general facts to such specific issues as: bioinformatics databases; molecular modeling; data visualization; The first, the cancer Translational Research Informatics Platform, caTRIP is a framework developed by Duke University to query and mine clinical, pathology, gene expression, and proteomics data. Recruitment and Retention of Bioinformatics and Research Staff . The cancer community has created such a next-generation World Wide Web, the Cancer Biomedical Informatics Grid (caBIG). Topics include the methods and results of functional and structural gene analysis on a genome-wide scale as well as a discussion of the implications of this research. We expect such successes to be reported within the next decade. It is a discipline that combines the studies of living systems with computer science and maths. Here are some of the topics in computer technology and computer science that you can consider. Filter Results . For a protein to be a suitable target, its appropriate role in the disease process is only one factor. I have 10 years as a programmer, focused on data. Discipline. However, bioinformatics has been instrumental in the advance of disease diagnosis and prognosis as well as therapy selection. Bioinformatic algorithms and tools are crucial tools in analyzing the data. Research Areas: Computer Science Education, Learning Sciences; Independent Research Topics: Please contact me if you have an interest in using computing to model the knowledge or skills of others. Statistical Applications in Computational Biology While much of our work is directed at concrete biomedical application scenarios, we also engage in research on methods. However, the discipline is not new. I am thinking I want to do something more interesting. I. Xenarios, in Comprehensive Biomedical Physics, 2014. This is mainly due to its flexibility, and data handling and modeling capabilities. Bioinformatics Research Opportunities All the faculty on this list should be considered to be preapproved. The caB2B application manages the flow of work necessary to make basic scientific discoveries and translate these into clinical research settings. Bioinformatics, as a new emerging discipline, combines mathematics, information science, and biology and helps answer biological questions. Computer Science and BioInformatics Bioinformatics merges biology, computer science and information technology to form a single new discipline. Major research efforts in the field include sequence alignment, gene finding, genome assembly, protein structure alignment, protein structure prediction, prediction of … oʊ ˌ ɪ n f ər ˈ m æ t ɪ k s / is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. 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